A Review of SPECT/CT Technology, Radiochemistry, and Emerging Applications

Twenty years after the commercial introduction of SPECT/CT, lessons learned during its development are reviewed and emerging applications are presented.

Course ID: Q00660 Category:
Modalities: ,


Satisfaction Guarantee


Targeted CE per ARRT’s Discipline, Category, and Subcategory classification:
[Note: Discipline-specific Targeted CE credits may be less than the total Category A credits approved for this course.]

Nuclear Medicine Technology: 1.00
Procedures: 1.00
Other Imaging Procedures: 1.00


  1. Introduction
  2. Pioneering Early Years
  3. If a Little is Great, is More Better
  4. Coming of Age and Ready for Prime Time
    1. High-Level Features Coming Together
    2. Precision Medicine as Breakthrough Application
    3. Leveraging the Full Diagnostic Power of SPECT/CT
  5. Progress in Physics and Engineering
    1. Innovation in Detector and Collimator Design
    2. The Next Major Leap Forward
  6. Innovations and Challenges in SPECT Radiopharmaceutical Development
    1. Strength and Challenges of SPECT Radionuclides
    2. Innovations in SPECT Tracers for Imaging and Treatment
  7. Conclusion


Upon completion of this course, students will:

  1. be familiar with the limitations of the first commercial SPECT/CT imaging devices
  2. identify the past clinical barriers of the early SPECT/CT imaging systems
  3. be familiar with the remaining challenge in physics and engineering in SPECT/CT
  4. identify what year 64 slice CT capabilities emerged on SPECT/CT systems
  5. be familiar with confusing terminology used in describing early CT acquisition protocols
  6. identify the technique used to reduce radiation exposure when performing SPECT/CT
  7. identify the year absolute quantification became available when performing SPECT/CT
  8. be familiar with the application of 177Lu in nuclear medicine
  9. identify the SPECT/CT requirements to determine individualized dosimetry
  10. be familiar with the percentage of in vivo accuracy of SPECT/CT quantification of 177Lu-prostate specific membrane antigen.
  11. identify the indication for developing the clinical application of high-end bone SPECT/CT
  12. be familiar with the characteristics of CZT detectors as compared with traditional NaI detectors
  13. identify the advantages of using CZT detectors when performing SPECT/CT
  14. be familiar with the spatial resolution of CZT SPECT imaging systems
  15. recognize the SPECT/CT gantry design that is leading to a paradigm shift in nuclear medicine
  16. recognize the materials used to craft novel collimators for CZT SPECT systems
  17. understand what is required to provide reproducible, consistent, and accurate standardization
  18. be familiar with the organizations that would assist in standardizing SPECT/CT quantification
  19. identify the radionuclide used in 85% of all diagnostic nuclear medicine procedures
  20. be familiar with the strengths of SPECT dual-isotope imaging
  21. identify the first small-molecule prostate-specific membrane inhibitor radiotracers
  22. be familiar with the use of 99mTc-duramycin
  23. be familiar with the use of 99mTc-HYNIC-c-Met-binding peptide
  24. recognize the characteristics of ideal theranostic radionuclides
  25. identify the imaging modality often benchmarked against SPECT/CT