Abdominal and Pelvic Complications of Nonoperative Oncologic Therapy

This course has been approved for 3.0 Category A credits.
No discipline-specific Targeted CE credit is currently offered by this course.

Outline

1. Introduction
   1. Chemotherapeutic Agents
   2. Radiation Therapy
2. Effects of Chemotherapy
   1. Liver
      1. Fat Deposition
      2. Hepatic Capsular Retraction
      3. Portal Vein Thrombosis
      4. Hepatic Veno-occlusive Disease
      5. Hepatic Congestion
   2. Spleen
      1. Splenic Rupture
      2. Therapy-induced Splenomegaly
      3. Spleen after Use of Thorotrast
   3. Pancreas
   4. Bowel
      1. Enteritis
      2. Colitis
   5. Bowel Perforation, Fistulas, and Delayed Anastomotic Leak
      1. Perforation and Fistula
      2. Delayed Anastomotic Leak
      3. Graft-Versus-Host Disease
      4. Pneumatosis
   6. Vessels
      1. Vascular Complications
      2. Bleeding
      3. Peritoneum and Mesentery
3. Radiation-induced Changes
   1. Liver
   2. Pancreas
   3. Spleen
   4. Stomach and Duodenum
   5. Small Bowel
   6. Large Bowel and Presacral Space
   7. Kidney, Ureter, and Bladder
   8. Bone
   9. Radiation-induced Tumors
4. Summary

Objectives

Upon completion of this course, students will:

1. know the cell types affected by cytotoxic agents
2. be familiar with Topoisomerase inhibitors and other chemotherapeutic agents
3. be familiar with targeted chemotherapeutic agents, their indications and side effects
4. be familiar with the complications of chemotherapeutic agents by organ
5. be familiar with the complications of chemotherapeutic agents
6. understand why a clinician should be alerted to imaging findings of steatosis or steatohepatitis
7. be familiar with the appearance of hepatic capsular retraction on CT and MR
8. know the patient symptoms of hepatic veno-occlusive disease
9. identify the possible method of differentiation between hepatic veno-occlusive disease and graft-versus-host disease
10. be familiar with the imaging findings of hepatic veno-occlusive disease
11. understand the issue of administering imatinib in conjunction with clopidogrel
12. know how splenic rupture demonstrates at CT imaging
13. be familiar with the symptoms of therapy-induced splenomegaly with which patients may present
14. be familiar with the appearance of pancreatitis at CT imaging
15. know how a pseudomembranous colitis diagnosis is confirmed
16. be familiar with the CT imaging findings of a delayed anastomotic leak
17. know the conditions for which patients are receiving chemotherapeutic agents which can cause pneumatosis
18. know the clinical clues to the presence of hemorrhage
19. be familiar with the radiation damage progression pathway in the liver
20. be familiar with how radiation damaged liver tissue appears at imaging
21. be familiar with the presentation of chronic radiation injury to the liver
22. be familiar with the secondary signs of pancreatic tumor recurrence
23. understand the effects of irradiation of the spleen
24. be familiar with the findings of acute radiation injury when irradiating the stomach and duodenum for retroperitoneal and upper abdominal tumors