Breast and Ovarian Cancer Screening of BRCA Mutation Carriers

A review of the current screening guidelines for breast and ovarian cancers in patients who test positive for BRCA mutation along with the imaging features that are suspicious for early breast and ovarian cancers.

Course ID: Q00595 Category:
Modalities: , , ,

3.5

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Targeted CE per ARRT’s Discipline, Category, and Subcategory classification:
[Note: Discipline-specific Targeted CE credits may be less than the total Category A credits approved for this course.]

Breast Sonography: 3.50
Patient Care: 2.00
Patient Interactions and Management: 2.00
Procedures: 1.50
Pathology: 1.00
Breast Interventions: 0.50

Mammography: 3.50
Patient Care: 1.25
Patient Interactions and Management: 1.25
Procedures: 2.25
Anatomy, Physiology, and Pathology: 1.00
Mammographic Positioning, Special Needs, and Imaging Procedures: 1.25

Magnetic Resonance Imaging: 1.00
Procedures: 1.00
Body: 1.00

Registered Radiologist Assistant: 1.75
Procedures: 1.75
Abdominal Section: 0.25
Thoracic Section: 1.50

Sonography: 2.00
Procedures: 2.00
Gynecology: 1.00
Superficial Structures and Other Sonographic Procedures: 1.00

Radiation Therapy: 2.25
Patient Care: 1.25
Patient and Medical Record Management: 1.25
Procedures: 1.00
Treatment Sites and Tumors: 1.00

Outline

  1. Introduction
  2. Prevalence of Cancer risk
  3. Risk Assessment Models
  4. Guidelines on Genetic Screening and Clinical Management of Patients with BRCA Genetic Mutation
  5. Breast Cancer
    1. Histopathology
  6. Screening tools and Algorithms
    1. Mammographic Imaging
    2. Digital Breast Tomosynthesis
    3. US Screening
    4. Dynamic Contrast Material-enhanced MRI
    5. Imaging Requirements for Screening for Breast Cancer
    6. Imaging Diagnosis of Breast Cancer
  7. Ovarian Cancer
    1. Histopathology
    2. Screening Tools and Algorithms
    3. Imaging Requirements for Screening for Ovarian Cancer
    4. Imaging Appearance of Early Ovarian Cancer
  8. Conclusion

Objectives

Upon completion of this course, students will:

  1. state the most common cancer in women
  2. state the 5th most common cancer in women
  3. describe familial cancer
  4. compare breast and ovarian cancer rates associated with inheritable genetic mutations
  5. list the genes associated with the most common genetic mutations implicated in hereditary breast and ovarian cancer
  6. document the prevalence of the BRCA genetic mutation in the general population
  7. list the populations most at risk for BRCA founder mutations
  8. recall the estimated lifetime risk for ovarian cancer in BRCA1 mutation carriers
  9. list other cancers that BRCA1 and BRCA2 carriers are at increased risk for
  10. list the requirement of an accurate cancer risk assessment
  11. state how many cancer prediction models there are available
  12. know what the CA-125 abbreviation stands for
  13. interpret table in article to determine criteria for consideration for referral to a cancer genetics specialist
  14. recall how bilateral prophylactic mastectomy may reduce the incidence of breast cancer in those with BRCA genetic mutation
  15. list cancer screening options for women with ovarian cancer risks
  16. summarize the societal and national screening guidelines for breast and ovarian cancers in patients who test positive for BRCA mutation
  17. state the characteristics of BRCA1-associated breast carcinomas
  18. define BRCA2-associated breast carcinomas
  19. state which imaging modality is proven to decrease mortality from breast cancer
  20. choose the imaging modality that is preferred for screening women with the BRCA mutation over screen-film mammography
  21. recall the digital breast tomosynthesis detection rate for invasive breast carcinoma
  22. state the imaging modality used as a supplemental screening tool when there is a contraindication to MR screening for patients who test positive for the BRCA mutation
  23. identify the imaging modality that is the most sensitive screening modality for BRCA mutation carriers
  24. state the sensitivity range for MR imaging
  25. locate table within the article that summarizes the prospective screening trials for breast cancer in patient with an increased risk for breast cancer
  26. compare the outcomes in the Dutch prospective multicenter MR imaging screening study
  27. list the outcomes of modeling studies based on data from MRI screening trials
  28. list the standard mammography screening views
  29. list the modality that should be used for breast cancer screening in younger patients with dense breast tissue
  30. state the average scan time for standard full-dynamic contrast-enhanced breast MR imaging protocol
  31. describe how BRCA-associated breast cancers appear at mammography
  32. list modalities that should be used when new imaging findings are depicted at screening mammography in BRCA carriers
  33. state the second most common MR presentation of BRCA-related cancers
  34. state the precursor lesion to high-grade serous carcinoma
  35. express at what stage the majority of ovarian cancers are diagnosed
  36. list the health risks associated with surgically induced early menopause
  37. state the most widely accepted protocol for ovarian cancer screening in women at high risk
  38. describe the UK Collaborative Trial in Ovarian Cancer Screening
  39. list the lesion types of which ultrasound with Doppler examination is excellent at characterizing
  40. state the imaging modality utilized to evaluate adnexal lesions that are indeterminate at ultrasound
  41. recall the section thickness for T2-weighted and contrast-enhanced T1-weighted images for ovarian screening
  42. list what can be done 4-6 hours prior to abdominal MR imaging in order to optimize the examination
  43. state the survival rate for women with stage 1 ovarian cancer
  44. state the stage at which most ovarian cancers are diagnosed
  45. list symptoms that carry a broad differential diagnosis and overlap with symptoms of women with ovarian cancer