Molecular Body Imaging with MRI, CT and US, Part II

This course has been approved for 3.5 Category A credits.
No discipline specific Targeted CE credit is currently offered by this course.

Outline

1. Introduction
2. Applications of Molecular and Cellular MR Imaging
   1. Oncology
   2. Cardiovascular Application
   3. Inflammation
   4. Metabolic Imaging
   5. Cell Tracking
3. Applications of Molecular CT Imaging
4. Applications of Molecular US Imaging
   1. Imaging of Inflammation
   2. Imaging of Thrombus Formation
   3. Imaging of Tumor Angiogenesis
   4. Steps toward Clinical Translation of Molecular US Imaging
5. Outlook

Objectives

Upon completion of this course, students will:

1. recognize the most commonly used cross-sectional diagnostic imaging techniques
2. identify the mechanisms of molecular MR imaging
3. understand the fundamentals of diffusion-weighted MR imaging
4. identify the characteristics of ultrasmall superparamagnetic iron oxide particles
5. learn the properties of integrins
6. identify which imaging modalities use integrins as molecular imaging targets
7. understand the process of tumor cell marker imaging
8. become familiar with the history of antibody research
9. understand the process of hybridoma creation
10. become familiar with techniques for antibody-based radionuclide imaging
11. become familiar with techniques for antibody-based radionuclide therapy
12. identify targets of molecular MR imaging of the cardiovascular system
13. recognize the usefulness of molecular MR imaging with avb3 integrin
14. identify the various hyperpolarized agents used for MR metabolic imaging
15. identify cyclotron-produced PET radionuclides
16. identify PET radiopharmaceuticals used for imaging prostate cancer
17. recognize the drawbacks of PET imaging of metabolites
18. recognize the barriers to cell tracking with gadolinium-based MR contrast agents
19. understand the image effect caused by SPIO nanoparticles
20. identify the cell types that demonstrate uptake of unmodified SPIO nanoparticles
21. recognize the benefits of using fluorine-19 for cell tracking with MR imaging
22. identify the targets of nuclear medicine-based cell tracking
23. understand the process of labeling cells with radioisotopes
24. recognize the FDA-approved processes for labeling cells with radioisotopes
25. identify potential molecular CT contrast agents
26. understand the obstacles to molecular CT imaging
27. identify the concentration of gadolinium-based contrast agents required for MR imaging
28. identify the modality that can image individual molecular contrast agent particles
29. identify the modalities that can use vascular cell adhesion molecule-1 as a molecular target
30. understand the applications of VCAM-1–targeted US microbubbles
31. understand the applications of P-selectin–targeted US microbubbles
32. identify the modalities that can use avb3 integrin as a molecular target
33. recognize the benefits of US that promote its use in treatment response monitoring
34. identify the challenges preventing MR, CT and US from becoming molecular imaging techniques
35. identify the imaging modality with the highest sensitivity for detection of contrast agents
36. identify methods for increasing sensitivity for molecular MR imaging
37. identify methods for increasing sensitivity for molecular CT imaging
38. understand the greatest challenge for the molecular imaging community
39. become familiar with the process for bringing a new imaging agent to market
40. understand the effect of creating less-specific molecular contrast agents